leeds

University of Leeds

The University of Leeds is ranked within the top 100 universities in the QS world rankings, and is one of the largest universities in the UK with an annual income in excess of €907m and over 30,000 students from 141 countries. The Faculty of Biological Sciences, is one of the UKs biggest groupings of bioscience researchers, with over 100 academic staff, 150 post-doctoral researchers, and over €55 million research portfolio. The Faculty runs several thriving postgraduate research schemes, with a total of over 200 PhD candidates, and 140 MSc candidates. The Faculty of Biological Sciences houses the Astbury Centre For Structural Molecular Biology, which has world-leading state-of-the-art research infrastructure. Specific for this current project, this includes: In-house X-ray generator and detector, 950, 750 and 600 MHz NMR spectrometers, two 300 KeV Titan Krios electron microscopes with direct electron detectors, ITC, SPR, CD, protein purification suite with HPLC, robotic crystallization condition screening.

Web page: www.fbs.leeds.ac.uk

Key publications

  • Surtees, RA, et al, Barr, JN and Edwards, TA (2015). The crystal structure of the Hazara virus nucleocapsid protein (2015) BMC Structural Biology, Dec 29; 15(1):24.
  • Tanner SJ. et al and Edwards, TA. and Barr, JN (2014)Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proc Natl Acad Sci U S A. Jan 28;111(4):1580-5.
  • Ariza, A., et al and Barr, JN. and Edwards, TA (2013). Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research. June, 41. P5912-26.
  • Carter, SD., et al Edwards, TA and Barr, JN (2012). Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. J Virol. Oct;86(20):10914-23.
  • Caygill RL et al, Millner PA (2012) Novel impedimetric immunosensor for the detection and quantitation of adenovirus using reduced antibody fragments immobilized onto a conducting copolymer surface. Biosens Bioelectron 32 104-110

Staff involved in HONOURs

Prof dr. John N. Barr

       John_Barr

Prof. dr. John N. Barr has over 20 years’ experience in negative strand RNA virology, with expertise in molecular, cellular and structural biology. He will act as primary supervisor for two ESR-11 and ESR-14 and co-supervision of ESR-10 hosted at both Leeds and INGENASA.

Dr Thomas Edwards

       Thomas_Edwards

Dr. Thomas Edwards has over 20 years of experience in structural molecular biology with a focus on RNA binding proteins and their structural biology, as well as the design of small molecule inhibitors. He is the lead academic for the macromolecular crystallisation unit at Leeds as well as the protein production facility. He will co-supervise ESR-11 and ESR-14 at Leeds.

Prof dr. Paul A. Millner

       PAUL Millner2016B

Prof. dr. Paul A. Millner is the expert in Electrochemical and optical biosensor development, a technique that allows highly sensitive single step measurement of a wide range of substances. His group uses  Biosensors and Bionanotechnology for interrogation of analytes as well as catalysis on surfaces. Paul Millner will co-supervise ESR-14.

HONOURs

Host switching pathogens, infectious outbreaks and zoonosis; a Marie Sklodowska-Curie Innovative Training Network.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 721367.