Atypical Porcine Pestivirus Circulation and Molecular Evolution within an Affected Swine Herd

Alba Folgueiras-González, Robin van den Braak, Bartjan Simmelink, Martin Deijs, Lia van der Hoek and Ad de Groof

Although recently discovered, atypical porcine pestivirus (APPV) has circulated in pig farms for decades, causing outbreaks of congenital tremor with different grades of severity. Folgueiras-González et al studied APPV during 6 years in an affected swine herd. Throughout the years the herd showed some congenital tremor in the newborns, with peaks in 2013 and 2016. Genetic characterization of the APPV strains displayed each time the same genotype, indicating that there were no introductions from outside the farm. At the same time immune pressure affecting transmission of the virus in the herd was most probably low since genetic characterization of the viruses showed mainly purifying selection.

Printed September 2020 in Viruses, Special Issue Bovine Viral Diarrhea Virus and Related Pestiviruses

       Alba APPV on the farm


Host switching pathogens, infectious outbreaks and zoonosis; a Marie Sklodowska-Curie Innovative Training Network.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 721367.