Mutagenic analysis of Hazara nairovirus non-translated regions during single and multi-step growth identifies both attenuating and functionally-critical sequences for virus replication

Daniele F. Mega, Jack Fuller, Beatriz Álvarez-Rodríguez, Jamel Mankouri, Roger Hewson, John N. Barr

Nairoviruses are a group of RNA viruses that include many serious pathogens of humans and animals, including one of the most serious human pathogens in existence, Crimean-Congo hemorrhagic fever virus. This study represents the first mutagenic analysis of nairoviral non-translated regions in the context of the infectious cycle.

Published September 2020 in Journal of Virology

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Host switching pathogens, infectious outbreaks and zoonosis; a Marie Sklodowska-Curie Innovative Training Network.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 721367.